Several prominent cardinals are being discussed as potential successors in the Catholic Church. Cardinal Peter Erdo of Hungary, with his extensive European connections and involvement in key Vatican events, enjoys considerable esteem among European cardinals.

Cardinal Reinhard Marx of Germany, a close advisor to Pope Francis, is viewed with skepticism by conservatives due to his support for progressive reforms in the German church. Cardinal Marc Ouellet of Canada, who long headed the Vatican's office for bishops, brings experience in Latin America and a complex history involving the handling of clergy abuse cases.

Cardinal Pietro Parolin of Italy, the current Secretary of State, is considered a leading contender due to his high-ranking position, although his lack of direct pastoral experience and association with a Vatican financial scandal could be drawbacks. Cardinal Robert Prevost of the United States, with significant experience in Peru and currently overseeing bishop appointments, faces the historical reluctance towards an American pope and concerns about his potential for a long papacy. Cardinal Robert Sarah of Guinea, a favorite among conservatives, might be hampered by past disagreements with Pope Francis.

Cardinal Christoph Schoenborn of Austria, a former student of Benedict XVI, has shown openness to some of Francis' more debated initiatives. Cardinal Luis Tagle of the Philippines is seen as a possible first Asian pope and a close collaborator with Francis in the Vatican's missionary efforts. Finally, Cardinal Matteo Zuppi of Italy, known for his progressive views and work with the Sant'Egidio Community, aligns with Pope Francis' emphasis on ministering to marginalized communities, though his relative youth might be a consideration for some electors.